https://www.calolab.mit.edu/home daily 1.0 2026-03-02 https://images.squarespace-cdn.com/content/v1/60f9ecbd6b35063ee8c7587f/1635520186085-A60VLQO4BS2GOQHD94QY/GettyImages-486716026.jpg Home - Ribosomes in Development and Disease Ribosome assembly and function are regulated during development. Defects in ribosome assembly or function result in tissue specific disorders. We use zebrafish as a model system to study the developmental and tissue specific functions of ribosomes. https://images.squarespace-cdn.com/content/v1/60f9ecbd6b35063ee8c7587f/1635520230178-BULVU8CT8PNXFDA0XFNM/GettyImages-1204449227.jpg Home - Growth and Protein Synthesis Control in Stem Cells All the proteins in a cell are synthesized by ribosomes in a highly regulated manner. Protein synthesis rates vary across different tissues and even within closely related cell types in the same tissue. Stem cells exhibit lower rates of protein synthesis compared to their progenitor cells. We aim to better understand how ribosomes ensure adequate protein synthesis rates in stem cells. https://images.squarespace-cdn.com/content/v1/60f9ecbd6b35063ee8c7587f/1635520267201-D9HT3BR3LGUI4L2NDRFB/GettyImages-186735444.jpg Home - High-Order Assemblies Ribosomes are assembled in the nucleolus, a multi-component membraneless organelle in the cell nucleus. The architecture of the nucleolus and its assembly into compartments and sub-compartments rely on the unique physical and chemical properties of nucleolar proteins and nucleic acids. By concentrating molecules into compartments while allowing dynamic interactions, the nucleolus very efficiently facilitates the complex biochemical reactions that lead to the assembly of ribosomes. Our goal is to better understand how the organization of cellular matter in this membraneless organelle contributes to its various functions, particularly those related to health, aging, and disease. https://www.calolab.mit.edu/our-team daily 0.75 2026-03-21 https://images.squarespace-cdn.com/content/v1/60f9ecbd6b35063ee8c7587f/53ed0e8b-095e-41ea-b8c7-a330d4917991/DSC_0856.jpg Our Team https://images.squarespace-cdn.com/content/v1/60f9ecbd6b35063ee8c7587f/99dca1e9-90fb-481e-8de9-4138f2659dfc/DSC_0860.jpg Our Team https://images.squarespace-cdn.com/content/v1/60f9ecbd6b35063ee8c7587f/0721acd2-5371-46c7-b8e4-b08e63ba5f70/DSC_0877.jpg Our Team https://images.squarespace-cdn.com/content/v1/60f9ecbd6b35063ee8c7587f/4c572c96-8cd1-497e-ac9d-12de125efa50/DSC_0858.jpg Our Team https://images.squarespace-cdn.com/content/v1/60f9ecbd6b35063ee8c7587f/ebe5043d-ed88-45f7-a2d6-854918f2d70f/DSC_0867.jpg Our Team https://images.squarespace-cdn.com/content/v1/60f9ecbd6b35063ee8c7587f/45ed77eb-8029-434d-9729-9698affd22ad/DSC_0847.jpg Our Team https://images.squarespace-cdn.com/content/v1/60f9ecbd6b35063ee8c7587f/b10ca7b7-7730-43d6-8c73-b0e11ab4bc4d/DSC_0853.jpg Our Team https://images.squarespace-cdn.com/content/v1/60f9ecbd6b35063ee8c7587f/a0e481f8-a582-4b81-8019-361b1916f69e/DSC_0851.jpg Our Team https://images.squarespace-cdn.com/content/v1/60f9ecbd6b35063ee8c7587f/31895b66-01cc-4e8e-9733-52bf196eeeb8/DSC_0865.jpg Our Team https://images.squarespace-cdn.com/content/v1/60f9ecbd6b35063ee8c7587f/a43a1557-f171-431a-9514-36f09472dddd/DSC_0863.jpg Our Team https://www.calolab.mit.edu/publications daily 0.75 2026-03-02 https://www.calolab.mit.edu/donate daily 0.75 2026-03-03